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Tolvaptan-d7
$450
Only 1000 item(s) left in stock.
Products Details
Product Description
– Tolvaptan-d7 is the deuterium labeled Tolvaptan. Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation[1][2].
Web ID
– HY-17000S
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C26H18D7ClN2O3
References
– [1]Friedman B, Cirulli J.
Hyponatremia in critical care patients: Frequency, outcome, characteristics, and treatment with the vasopressin V(2)-receptor antagonist tolvaptan.
J Crit Care. 2012 Aug 8.|[2]Inomata T.
Tolvaptan (vasopressin receptor antagonist).Nihon Rinsho. 2011 Nov;69 Suppl 9:408-11.|[3]Vaduganathan M, Gheorghiade M, Pang PS, Konstam MA, Zannad F, Swedberg K, Grinfeld L, Burnett JC Jr, Krasa HB, Zimmer C, Blair J, Ouyang J, Maggioni AP; EVEREST investigators.
Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment.
J Cardiovasc Med (Hagerstown). 2012 Jul;13(7):415-22.|[4]Y Yamamura et al. OPC-41061, a Highly Potent Human Vasopressin V2-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats. J. Pharmacol.
Exp. Ther. 1998, 287(3), 860-867.|[5]RW Schrier et al. Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia. N Engl J Med 2006, 355, 2099-2112.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1246818-18-7
Molecular Weight
– 455.98
SMILES
– O=C(C1=C(C=C(C=C1)NC(C2=C(C([2H])=C([2H])C([2H])=C2[2H])C([2H])([2H])[2H])=O)C)N3C4=CC=C(Cl)C=C4C(CCC3)O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease; Endocrinology; Cancer
Solubility
– 10 mM in DMSO
Target
– Autophagy;Isotope-Labeled Compounds;Vasopressin Receptor
Isoform
– V2 ReceptorÂ
Pathway
– Autophagy;GPCR/G Protein;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
