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CFTR(inh)-172
$36 – $460
Products Details
Product Description
– CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
Web ID
– HY-16671
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C18H10F3NO3S2
References
– [1]Taddei A, et al. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30;558(1-3):52-6.|[2]Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8.
CAS Number
– 307510-92-5
Molecular Weight
– 409.40
Compound Purity
– 99.25
SMILES
– S=C(S/1)N(C2=CC=CC(C(F)(F)F)=C2)C(C1=CC3=CC=C(C=C3)C(O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Autophagy;CFTR
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
