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SIRT-IN-1
$250 – $1,800
Products Details
Product Description
– SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
Web ID
– HY-16615
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H27N5O2S
References
– [1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.
CAS Number
– 1431411-60-7
Molecular Weight
– 389.52
Compound Purity
– 98.58
SMILES
– NC(C1=CC2=NC=NC(N3CCC(CCNC(C(C)(C)C)=O)CC3)=C2S1)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Neurological Disease; Cancer; Inflammation/Immunology
Solubility
– DMSO : 19.23 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Sirtuin
Isoform
– SIRT1;SIRT2;SIRT3
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
