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Products Details
Product Description
– GGTI-2417 is a potent and selective inhibitor of GGTase I. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27Kip1 at Thr187 and accumulates p27Kip1 in the nucleus. GGTI-2417 also induces breast cancer cell apoptosis[1].
Web ID
– HY-16230
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H33N5O4
References
– [1]Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63.
CAS Number
– 501010-05-5
Molecular Weight
– 455.55
SMILES
– CC(C)C[C@@H](C(OC)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;ROS Kinase
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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