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PS-1145
$54 – $1,260
Products Details
Product Description
– PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
Web ID
– HY-18008
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H11ClN4O
References
– [1]Hideshima T, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10;277(19):16639-47.|[2]Vodanovic-Jankovic S, et al. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood. 2006 Jan 15;107(2):827-34.|[3]Oh-I S, et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E47-53.
CAS Number
– 431898-65-6
Molecular Weight
– 322.75
Compound Purity
– 99.88
SMILES
– O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 20.83 mg/mL (ultrasonic)
Target
– Apoptosis;IKK
Isoform
– IKK
Pathway
– Apoptosis;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
