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Products Details
Product Description
– AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo[1].
Web ID
– HY-160045
Shipping
– Room temperature
Molecular Formula
– N/A
References
– [1]Clawson GA, Abraham T, Pan W, Tang X, Linton SS, McGovern CO, Loc WS, Smith JP, Butler PJ, Kester M, Adair JH, Matters GL. A Cholecystokinin B Receptor-Specific DNA Aptamer for Targeting Pancreatic Ductal Adenocarcinoma. Nucleic Acid Ther. 2017 Feb;27(1):23-35.
Molecular Weight
– N/A
SMILES
– [AP1153 aptamer (sodium)]
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Cholecystokinin Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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