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Products Details
Product Description
– AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
Web ID
– HY-15971A
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C24H38N6
Citations
– Br J Haematol. 2022 Dec 19.|Biomed Pharmacother. 2021 Mar 24;138:111476.|J Labelled Comp Radiopharm. 2018 May 15;61(5):438-446. |Patent. US20180263995A1.
References
– [1]Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67(2):651-8.|[2]Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70(5):752-61.
CAS Number
– 185991-24-6
Molecular Weight
– 410.60
SMILES
– C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1
Clinical Information
– No Development Reported
Research Area
– Infection; Endocrinology
Solubility
– 10 mM in DMSO
Target
– CXCR;HIV
Isoform
– CXCR4;HIV-1;HIV-2
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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