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Products Details
Product Description
– Antitumor agent-99 (compound 7) is an anticancer agent targeting FRα/β and PCFT. Antitumor agent-99 inhibits R2/PCFT4 (PCFT), RT16(FRα), and D4(FRβ) cells with IC50s of 51.46 nM, 2.53 nM, and 2.98 nM, respectively[1].
Web ID
– HY-157217
Shipping
– Room temperature
Molecular Formula
– C19H21N5O6S
References
– [1]Kaku K et al. Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport[J]. ACS Medicinal Chemistry Letters, 2023.
Molecular Weight
– 447.46
SMILES
– O=C(N[C@H](C(O)=O)CCC(O)=O)C1=CC=C(CCC2=C(C)NC(N=C(N3)N)=C2C3=O)S1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Antifolate
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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