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Products Details
Product Description
– LWY713 is a FLT3 degrader (DC50=0.64 nM) that selectively induces FLT3 degradation in a cereblon- and proteasome-dependent manner. LWY713 inhibits cell proliferation and induces G0/G1 arrest and apoptosis in MV4-11 cells. LWY713 exhibits potent in vivo antitumor activity in an MV4-11 xenograft model[1].
Web ID
– HY-157213
Shipping
– Room temperature
Molecular Formula
– C43H54N10O8
References
– [1]Liu W et al. Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2023 Nov 19;264:115974.
Molecular Weight
– 838.95
SMILES
– O=C1C2=CC=CC(OCC(N3CCN(C4CCN(C5=CC=C(C=C5OC)NC6=C(C(N)=O)N=C(CC)C(NC7CCOCC7)=N6)CC4)CC3)=O)=C2CN1C8C(NC(CC8)=O)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;FLT3
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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