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Products Details
Product Description
– EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S mutants. EGFR kinase inhibitor 2 has the potential to address acquired resistance in the treatment of non-small cell lung cancer[1].
Web ID
– HY-157166
Shipping
– Room temperature
Molecular Formula
– C39H40N6O5
References
– [1]Fan M et al. Design, synthesis and biological evaluation of EGFR kinase inhibitors that spans the orthosteric and allosteric sites. Bioorg Med Chem. 2023 Nov 10;96:117534.
Molecular Weight
– 672.77
SMILES
– COC1=C(C=C2C(N=CN=C2NCC3=CC=C(C=C3)NC(C(N4CC5=C(C4=O)C=CC=C5)C6=CC=CC=C6)=O)=C1)OCCCN7CCOCC7
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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