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Products Details
Product Description
– RIPK1/3-IN-1 (Compound 10) is a RIPK1 and RIPK3 inhibitor. RIPK1/3-IN-1 specifically inhibits necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation[1].
Web ID
– HY-157039
Shipping
– Room temperature
Molecular Formula
– C26H19F4N3O3S
References
– [1]Fang JJ, et al. Insight from Linker Investigations: Discovery of a Novel Phenylbenzothiazole Necroptosis Inhibitor Targeting Receptor-Interacting Protein Kinase 1 (RIPK1) from a Phenoxybenzothiazole Compound with Dual RIPK1/3 Targeting Activity. J Med Chem. 2023 Nov 2.
Molecular Weight
– 529.51
SMILES
– O=C(CC1=CC=CC(OC(F)(F)F)=C1)NC2=C(C=CC(C3=CC=C4N=C(SC4=C3)NC(C5CC5)=O)=C2)F
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– RIP kinase
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
