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Products Details
Product Description
– Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively.
Web ID
– HY-15685A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C15H18FN3O2S
Citations
– Adv Sci (Weinh). 2022 Mar 3;e2104682.|Curr Eye Res. 2023 May 22;1-12.|Mol Ther. 2023 Feb 28;S1525-0016(23)00116-8.|Preprints. 2023 May 15.|Science. 2017 Dec 1;358(6367):eaan4368.
References
– [1]Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39(8):813-22.|[2]Kaneko Y, et al. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm’s canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640.|[3]Yamamoto K, et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55(11):7126-36.
CAS Number
– 223645-67-8
Molecular Weight
– 323.39
SMILES
– FC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– ROCK
Isoform
– ROCK1;ROCK2
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
