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Products Details
Product Description
– FD2157 is a photosensitive PI3K inhibitor, with IC50s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light[1].
Web ID
– HY-155996
Shipping
– Room temperature
Molecular Formula
– C27H21ClN6O8S
References
– [1]Yang C, et al. Discovery of a photosensitizing PI3K inhibitor for tumor therapy: Design, synthesis and in vitro biological evaluation. Bioorg Med Chem Lett. 2023 Oct 1;94:129459.
Molecular Weight
– 625.01
SMILES
– O=C(OCC1=CC(OC)=C(OC)C=C1[N+]([O-])=O)N(N=C2)C(C2=C3)=NC=C3C4=CN=C(Cl)C(NS(=O)(C5=CC=CC=C5)=O)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PI3K
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
