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Products Details
Product Description
– PI3Kδ-IN-14 (Compound (S)-29) is a selective PI3Kδ inhibitor (IC50: 0.8 nM, Kd: 84.8 nM). PI3Kδ-IN-14 binds to the ATP-binding site of the kinase domain of PI3Kδ. PI3Kδ-IN-14 has anti-inflammatory activity by inhibiting the PI3K/AKT pathway. PI3Kδ-IN-14 ameliorates acute lung injury (ALI)[1].
Web ID
– HY-155975
Shipping
– Room temperature
Molecular Formula
– C26H20ClFN8O
References
– [1]Tang Y, et al. Discovery of Highly Selective and Orally Bioavailable PI3K未 Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury. J Med Chem. 2023 Aug 22.
Molecular Weight
– 514.94
SMILES
– ClC1=CC=C2C(N(N=C2[C@@H](N3C4=C(C(C5=CC(F)=C(C=C5)OC)=N3)C(N)=NC=N4)C)C6=CC=CN=C6)=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PI3K
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
