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Products Details
Product Description
– Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect[1].
Web ID
– HY-155851
Shipping
– Room temperature
Molecular Formula
– C26H47NO3
References
– [1]Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215.
CAS Number
– 444914-19-6
Molecular Weight
– 421.66
SMILES
– CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Ferroptosis;Glutathione Peroxidase;MDM-2/p53
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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