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Mibefradil (dihydrochloride)
$112 – $730
Products Details
Product Description
– Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively)[1].
Web ID
– HY-15553A
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C29H40Cl2FN3O3
Citations
– Front Pharmacol. 2022 Feb 23;13:816133.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Br J Pharmacol. 2021 Jan;178(2):346-362.|Eur J Pharmacol. 2021 Feb 5;892:173782.|Front Pharmacol. 23 February 2022.|J Cell Physiol. 2021 Mar 11.|Mediat Inflamm. 2020 Nov 10;2020:3691701.|Theriogenology. 2021 Jan 1;159:140-146.
References
– [1]Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11(3):1039-1044.|[2]Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35.|[3]Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597(16)30071-6.|[4]Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8.
CAS Number
– 116666-63-8
Molecular Weight
– 568.55
Compound Purity
– 98.85
SMILES
– O=C(O[C@@]1(CCN(CCCC2=NC3=CC=CC=C3N2)C)[C@@H](C(C)C)C4=C(C=C(F)C=C4)CC1)COC.[H]Cl.[H]Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– H2O : 150 mg/mL (ultrasonic)
Target
– Calcium Channel
Isoform
– L-type calcium channel;T-type calcium channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
