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Products Details
Product Description
– Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM). Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC50s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells[1].
Web ID
– HY-155231
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H21N3O5
References
– [1]Donarska B, et al. Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action. Bioorg Chem. 2023 Sep;138:106608.
Molecular Weight
– 383.40
SMILES
– O=C(C(N(CC1=C2C=CC=C1N3C(C(CC)(CC)C3=O)=O)C2=O)CC4)NC4=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Elastase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
