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Products Details
Product Description
– FLT3-IN-21 (compound LC-3) is a potent FLT3 inhibitor (IC50: 8.4 nM) and induces apoptosis. FLT3-IN-21 can arrest the cell cycle in the G1 phase and inhibit the proliferation of FLT3-ITD-positive AML cells MV-4-11 (IC50: 5.3 nM). In mice, FLT3-IN-21 (10 mg/kg/d) inhibited tumor growth in the MV-4-11 xenograft model (TGI=92.16%)[1].
Web ID
– HY-155226
Shipping
– Room temperature
Molecular Formula
– C20H22FN5O2
References
– [1]Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645..|[2]Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645.
Molecular Weight
– 383.42
SMILES
– CC1=C(NC=C1NC(NN2CCCCC2)=O)/C=C(C3=CC(F)=CC=C3N4)C4=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;FLT3
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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