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Product Description
– NMDA receptor antagonist 7 (Compound (S)-10a) is GluN2B subunit-selective NMDA Receptor antagonist, with an Ki of 93 nM and an IC50 of 72 nM. NMDA receptor antagonist 7 can be used for research of neurodegenerative diseases[1].
Web ID
– HY-155185
Shipping
– Room temperature
Molecular Formula
– C22H27N3O
References
– [1]Lüken J, et al. Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists. J Med Chem. 2023 Aug 24;66(16):11573-11588.
Molecular Weight
– 349.47
SMILES
– O[C@@H](CCN1CCC(CC2=CC=CC=C2)CC1)C3=CC(C=NN4)=C4C=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– iGluR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
