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Atrasentan (hydrochloride)
$120 – $780
Products Details
Product Description
– Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC50 of 0.0551 nM for ETA[1].
Web ID
– HY-15403A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H39ClN2O6
Citations
– Department Veterinary Clinical Medicine. University of Illinois. 2015.|J Vet Intern Med. 2015 Nov;29(6):1584-94.|Mol Immunol. 2019 Oct;114:10-18. |Commun Biol. 2022 Jul 28;5(1):750.|Eur J Pharmacol. 2019 Mar 12;852:142-150.
References
– [1]Yuyama H, et al. Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. Eur J Pharmacol. 2004 Sep 13;498(1-3):171-7.|[2]Banerjee S, et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 combination in prostate cancer. Cancer Res. 2007 Apr 15;67(8):3818-26.|[3]Weiss J, et al. Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro. Cancer Chemother Pharmacol. 2011 Oct;68(4):1093-8.
CAS Number
– 195733-43-8
Molecular Weight
– 547.08
Compound Purity
– 99.51
SMILES
– O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O.Cl
Clinical Information
– Launched
Research Area
– Cancer; Endocrinology; Cardiovascular Disease
Solubility
– 0.1 M HCL : < 1 mg/mL (ultrasonic;warming;adjust pH to 1 with HCl;heat to 60°C)|DMSO : 28.57 mg/mL (ultrasonic)|H2O : 0.5 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C)
Target
– Endothelin Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
