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Products Details
Product Description
– Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].
Web ID
– HY-153953
Shipping
– Room temperature
Molecular Formula
– C45H49ClFN7O8S
References
– [1]Kong Xianglong, et al. Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1.
CAS Number
– 2760536-88-5
Molecular Weight
– 902.43
SMILES
– O=S(NC(C(C=CC(N1C[C@H](N(CC1)CC2=C(C3=CC=C(C=C3)Cl)CC(C)(CC2)C)C)=C4)=C4OC5=CN=C(NC=C6)C6=C5)=O)(C7=CC([N+]([O-])=O)=C(C(F)=C7)NC[C@H]8COCCO8)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Isoform
– Bcl-2;Bcl-xL
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
