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Products Details
Product Description
– HER2-IN-14 (Compound 34) is an HER2 inhibitor with an IC50 of 18 nM. HER2-IN-14 also inhibits wt-EGFR with an IC50 of 6.3 μM[1].
Web ID
– HY-153557A
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H23ClF2N8O3
References
– [1]Ding Zhou, et al. Quinazoline derivatives as antitumor agents. Patent WO2020057511A1.
CAS Number
– 2414056-35-0
Molecular Weight
– 568.96
SMILES
– ClC(C=C1NC2=NC=NC3=C2C(O[C@@H]4C(F)(CN(CC4)C)F)=C(OC)C=C3)=C(C=C1)OC5=CC6=NC=NN6C=N5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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