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Zosuquidar
$200 – $730
Products Details
Product Description
– Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research[1][2][3].
Web ID
– HY-15255
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H31F2N3O2
Citations
– Antiviral Res. 2021 Jun 28;105124.|Biomed Pharmacother. 2020 Sep;129:110506.|Biomed Res Int. 2020 Nov 29;2020:8878158.|Blood Adv. 2020 Oct 27;4(20):5062-5077.|Cancer Cell. 2017 Apr 10;31(4):501-515.e8. |Crit Rev Anal Chem. 2021 Mar 10;1-15.|Drug Metab Dispos. 2017 May;45(5):449-456.|Exp Ther Med. 2020 Dec 7.|Pharmaceutics. 2021, 13(4), 559.|Biochem Biophys Res Commun. 2021 May.|Biomed Res Int. 2014;2014:850493. |J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 31;1092:72-81. |J Pharm Biomed Anal. 2012 Jul;66:232-9.|Viruses. 2020 Aug 17;12(8):901.
References
– [1]A H Dantzig, et al. Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 1996 Sep 15;56(18):4171-9.|[2]Ruoping Tang, et al. Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML). BMC Cancer. 2008 Feb 13;8:51.|[3]Larry D Cripe, et al. Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood. 2010 Nov 18;116(20):4077-85.
CAS Number
– 167354-41-8
Molecular Weight
– 527.60
Compound Purity
– 98.33
SMILES
– FC1([C@H]2[C@@H]1C3=C([C@@H](C4=CC=CC=C42)N5CCN(CC5)C[C@H](COC6=C7C=CC=NC7=CC=C6)O)C=CC=C3)F
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : 8.33 mg/mL (ultrasonic)
Target
– P-glycoprotein
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
