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Products Details
Product Description
– BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo[1].
Web ID
– HY-152201
Shipping
– Room temperature
Molecular Formula
– C20H22Cl2N6O
References
– [1]George H Vandeveer, et al. Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model. Bioorg Med Chem Lett. 2022 Dec 17;80:129108.
CAS Number
– 1374239-71-0
Molecular Weight
– 433.33
SMILES
– C[C@@H]1[C@@H](CCCN1C(CNC2=CC(Cl)=CC(Cl)=C2)=O)NC3=C4C=CNC4=NC=N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Btk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
