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Products Details
Product Description
– AXL-IN-14 is a potent and orally active AXL inhibitor with an IC50 value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity[1].
Web ID
– HY-152075
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C32H24F2N4O4
References
– [1]Zhengsheng Zhan, et al. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. J. Med. Chem. 2022.
CAS Number
– 2947506-65-0
Molecular Weight
– 566.55
SMILES
– FC1=CC(NC(C2=CN(C=C(C2=O)C3=CC=C(C=C3)F)C(C)C)=O)=CC=C1OC4=CC=NC5=C4OC6=CC=CC=C6N5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– TAM Receptor
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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