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Products Details
Product Description
– EGFR-IN-74 (Compound 21) is a potent EGFR inhibitor with an IC50 of 138 nM against EGFR L858R/T790M. EGFR-IN-74 induces cancer cell apoptosis[1].
Web ID
– HY-151981
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C32H28BrF3N6O4S
References
– [1]Kardile RA, et al. Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening and ADME predictions. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114889.
Molecular Weight
– 729.57
SMILES
– CCOC(C1=C(C2=CC(Br)=CC=C2N=C1N3C=CN=C3)N4CCN(CC4)C5=C(C=CC=C5)NS(=O)(C6=CC=C(C=C6)C(F)(F)F)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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