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Products Details
Product Description
– TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research[1].
Web ID
– HY-151966
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C55H70N8O9
References
– [1]Park S, et al. Discovery of pan-IAP degraders via a CRBN recruiting mechanism. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114910.
Molecular Weight
– 987.19
SMILES
– O=C(N[C@@H]1CCCC2=C1C=CC=C2)[C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C(C)(C)C)=O)CC4=C(C=CC(OCCCCCCCCNC(C(C5)CN5C(C=C6C7=O)=CC=C6C(N7C8CCC(NC8=O)=O)=O)=O)=C4)C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Caspase;IAP;PROTACs
Isoform
– Caspase 3;Caspase 7;cIAP-1;cIAP-2;XIAP
Pathway
– Apoptosis;PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
