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Products Details
Product Description
– PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC50: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria[1].
Web ID
– HY-151575
Shipping
– Room temperature
Molecular Formula
– C24H25Cl2N5OS
References
– [1]Galal KA, et al. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. J Med Chem. 2022 Oct 13;65(19):13172-13197.
CAS Number
– 2797225-47-7
Molecular Weight
– 502.46
SMILES
– O=C(C1=CC=C(NC2=NC=C(Cl)C(C3=CC=C(Cl)S3)=N2)C=C1)N4CCC(N5CCCC5)CC4
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– GSK-3
Pathway
– PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
