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Products Details
Product Description
– Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].
Web ID
– HY-151524
Shipping
– Room temperature
Molecular Formula
– C30H31FN4O4S
References
– [1]Anthony T Ginnetti, et al. Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis. Bioorg Med Chem Lett. 2022 Oct 15;74:128927.
CAS Number
– 1694638-70-4
Molecular Weight
– 562.65
SMILES
– O=S1(CCN(CC1)C2=CC=C(C3=C([C@@H]4CCCC[C@H]4C(NC5(CC5)C#N)=O)OC(C6=CC=C(C=C6)F)=N3)C=C2)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cathepsin
Isoform
– Cathepsin K
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
