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Products Details
Product Description
– Isotretinoin-d5 is the deuterium labeled Isotretinoin. Isotretinoin is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity[1][2][3].
Web ID
– HY-15127S
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H23D5O2
References
– [1]Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May;1(3):162-9.|[2]Dahl AR, et al. Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug;6(8):3015-24|[3]Bergoli RD, et al. Isotretinoin effect on alveolar repair after exodontia–a study in rats. Oral Maxillofac Surg. 2011 Jun;15(2):85-92.|[4]RamÃrez-Flores PN, et al. Isotretinoin and Thalidomide Down-Regulate c-MYC Gene Expression and Modify Proteins Associated with Cancer in Hepatic Cells. Molecules. 2021 Sep 22;26(19):5742.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Molecular Weight
– 305.47
SMILES
– [2H]C([2H])(C1=C(/C=C/C(C)=C/C=C/C(C)=CC(O)=O)C(C)(C)CCC([2H])1[2H])[2H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Autophagy;Endogenous Metabolite;Isotope-Labeled Compounds;RAR/RXR
Pathway
– Autophagy;Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
