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Products Details
Product Description
– EGFR/HER2/DHFR-IN-1 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2/DHFR-IN-1 is a multiple inhibitor of EGFR/HER2 kinase and DHFR, with IC50s of 0.153 μM, 0.108 μM, 0.291 μM, respectively. EGFR/HER2/DHFR-IN-1 arrests cell cycle at G1/S and induces cells apoptosis[1].
Web ID
– HY-151154
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H11BrN4O2S
References
– [1]Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.
CAS Number
– 2820126-37-0
Molecular Weight
– 379.23
SMILES
– O=C(C1=CSC2=NC=C(C3=CC=C(Br)C=C3)N21)NNC(C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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