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Products Details
Product Description
– JAK3-IN-13 is a potent, selective and orally active JAK3 inhibitor with IC50 values of 4728, 2039, 8, 365 nM for NK1, JNK2, JNK3, Tyk2, respectively. JAK3-IN-13 shows antiproliferative activity. JAK3-IN-13 induces cell cycle arrest at G0/G1 phase. JAK3-IN-13 shows antitumor activity[1].
Web ID
– HY-150688
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H33ClN6O5
References
– [1]Li S, et al. Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant. J Med Chem. 2022 Jul 20.
CAS Number
– 2803329-86-2
Molecular Weight
– 533.02
SMILES
– C=CC(NC1=CC(NC2=NC=C(Cl)C(O[C@H]3[C@](OC[C@H]4OC)([H])[C@]4([H])OC3)=N2)=CC=C1N(CCN(C)C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JNK
Isoform
– JNK1;JNK2;JNK3
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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