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INO-1001
$97 – $850
Products Details
Product Description
– INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2].
Web ID
– HY-15045
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H25N3O4S
References
– [1]Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60.|[2]Mason KA, et al. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26(1):1-5. Epub 2007 Jul 13.
CAS Number
– 501364-82-5
Molecular Weight
– 439.53
Compound Purity
– 98.19
SMILES
– O=C1NC2=C(C3=CC=CC=C31)CC4=C2C=CC(S(NCCCN5CCOCC5)(=O)=O)=C4
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 31.25 mg/mL (ultrasonic)
Target
– PARP
Isoform
– PARP
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
