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Products Details
Product Description
– SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research[1].
Web ID
– HY-149607
Shipping
– Room temperature
Molecular Formula
– C23H22Cl2N8O
References
– [1]Hou Q, et al. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers. J Med Chem. 2023 Oct 12;66(19):13646-13664.
CAS Number
– 2802453-88-7
Molecular Weight
– 497.38
SMILES
– N/C(N1CCN(CC1)C2=CN=C(C(N)=N2)C3=CC=CC(Cl)=C3Cl)=NC4=CC(OC)=C(C=C4)C#N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– SHP2
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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