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Products Details
Product Description
– PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule protein-targeting chimera (PROTACs) targeting the Androgen Receptor AR-V7. PROTAC AR-NTD antagonist 1 antagonizes the N-terminal domain of AR (AR-NTD), degrades AR-V7 protein, and induces apoptosis in prostate cancer (PC) cells. The efficiencies of PROTAC AR-NTD antagonist 1 in degrading AR-V7 in VCaP cells were 62.2% (1 μM) and 71.1% (5 μM), respectively[1].
Web ID
– HY-149434
Shipping
– Room temperature
Molecular Formula
– C41H47ClN6O7
References
– [1]Zhang B, et al. Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer. J Med Chem. 2023 Aug 24;66(16):11158-11186..
Molecular Weight
– 771.30
SMILES
– CC(C1=CC=C(OC[C@H](O)CCl)C=C1)(C)C(C=C2)=CC=C2OCCCCCC3=CN(CCCNC4=CC=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=C4)N=N3
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor;Apoptosis
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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