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Products Details
Product Description
– PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC50: 3.6 nM). PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%)[1].
Web ID
– HY-149429
Shipping
– Room temperature
Molecular Formula
– C26H28ClF3N4O3S
References
– [1]Kato T, et al. Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure. J Med Chem. 2023 Aug 24;66(16):11428-11446..
CAS Number
– 928023-21-6
Molecular Weight
– 569.04
SMILES
– ClC1=CC(CC(O)=O)=CC(OCCC2(N3CCCC3)CCN(C4=NC5=CC=C(N=C5S4)C(F)(F)F)CC2)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– PPAR
Pathway
– Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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