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Mirodenafil
$56 – $430
Products Details
Product Description
– Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc)[1][2][3].
Web ID
– HY-14930
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C26H37N5O5S
References
– [1]Park HJ, et al. Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. World J Mens Health. 2014 Apr;32(1):18-27.|[2]Kang BW, et al. Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. Alzheimers Res Ther. 2022 Jul 8;14(1):92.|[3]Roh JS, et al. Mirodenafil ameliorates skin fibrosis in bleomycin-induced mouse model of systemic sclerosis. Anim Cells Syst (Seoul). 2021 Nov 3;25(6):387-395.
CAS Number
– 862189-95-5
Molecular Weight
– 531.67
SMILES
– O=C1C(N(CC)C=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCCC)N1
Clinical Information
– Launched
Research Area
– Endocrinology; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Apoptosis;Glucocorticoid Receptor;Phosphodiesterase (PDE);Wnt;β-catenin
Isoform
– PDE5
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
