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Products Details
Product Description
– PI3Kδ-IN-12 (compound 13) is a PI3Kδ inhibitor (pIC50 = 5.8), with pKi values of 8.0/6.5/6.4/6.7 for PI3Kδ/γ/β/α, respectively. PI3Kδ-IN-12 can be used in the study of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)[1].
Web ID
– HY-149235
Shipping
– Room temperature
Molecular Formula
– C20H15Cl2N5O3
References
– [1]Mazzucato R, et al. Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors. Eur J Med Chem. 2023 Jun 5;254:115331.
Molecular Weight
– 444.27
SMILES
– NC(C1=C2NC(N(C2=NC(C3=CC(O)=CC=C3)=N1)CCC4=CC=C(C(Cl)=C4)Cl)=O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PI3K
Isoform
– PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
