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Products Details
Product Description
– Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].
Web ID
– HY-149092
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H15N3O2
References
– [1]Bae D, et al. Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis. Eur J Med Chem. 2023 May 5;251:115274.
CAS Number
– 2097497-16-8
Molecular Weight
– 317.34
SMILES
– O=C(/C(C1=C2C)=CC3=NC4=C(C=CC=C4)C=C3)NC1=NC(C)=C2O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– TAM Receptor
Isoform
– Axl
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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