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Products Details
Product Description
– PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) [1].
Web ID
– HY-149001
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H21N3O5
References
– [1]Eldin A Osman E, et al. Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. Bioorg Chem. 2020 Nov;104:104198.
CAS Number
– 2494000-71-2
Molecular Weight
– 359.38
SMILES
– O=C1NC(/C(C(N1)=O)=C/C2=CC(CN3CCCCC3)=C(O)C(OC)=C2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PARP
Isoform
– PARP1
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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