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Givinostat (hydrochloride monohydrate)
$90 – $890
Products Details
Product Description
– Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
Web ID
– HY-14842B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H30ClN3O5
Citations
– J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Acta Pharmacol Sin. 2021 Apr 13.|Cell Prolif. 2021 May 24;e13072.|Commun Biol. 2021 Oct 29;4(1):1235.|J Orthop Transl. 29 (2021) 106-112.|Neuroscience. 2021 Apr 13;S0306-4522(21)00185-8.|Cell Death Dis. 2020 Sep 15;11(9):753.
References
– [1]Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.|[2]Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.|[3]Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.
CAS Number
– 732302-99-7
Molecular Weight
– 475.97
Compound Purity
– 98.0
SMILES
– O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl.O
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 2.94 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– HDAC
Isoform
– HD1;HD2;HDAC1;HDAC10;HDAC11;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
