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Palifosfamide
$210 – $735
Products Details
Product Description
– Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity.
Web ID
– HY-14798
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C4H11Cl2N2O2P
References
– [1]Hingorani P, et al. Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol. 2009 Sep;64(4):733-40.|[2]Jones B, et al. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012 Feb;23(2):173-84.
CAS Number
– 31645-39-3
Molecular Weight
– 221.02
Compound Purity
– 97.0
SMILES
– O=P(NCCCl)(NCCCl)O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 40 mg/mL (ultrasonic)|H2O : 14.29 mg/mL (ultrasonic)
Target
– DNA Alkylator/Crosslinker;Drug Metabolite
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
