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Products Details
Product Description
– Inolitazone a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition.
Web ID
– HY-14792
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H26N4O4S
Citations
– Exp Cell Res. 2017 Dec 15;361(2):246-256. |Front Microbiol. 2019 Jan 8;9:3257.|Cancer Med. 2018 May;7(5):1955-1966. |Int J Oncol. 2018 Jun;52(6):1991-2000.
References
– [1]Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25(16):2304-17.|[2]Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69(4):1536-44.
CAS Number
– 223132-37-4
Molecular Weight
– 502.58
SMILES
– O=C(N1)SC(CC2=CC=C(OCC3=NC4=CC=C(OC5=CC(C)=C(N)C(C)=C5)C=C4N3C)C=C2)C1=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PPAR
Isoform
– PPARγ
Pathway
– Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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