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Products Details
Product Description
– PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC50 values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest[1].
Web ID
– HY-147913
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C34H51NO2
References
– [1]Wang SS, et al. Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway. Bioorg Chem. 2020 Aug;101:104036.
CAS Number
– 2457245-94-0
Molecular Weight
– 505.77
SMILES
– CC1(C)C(C(C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(NCC=C)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;Apoptosis;mTOR;PI3K
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
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