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Products Details
Product Description
– B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM[1].
Web ID
– HY-147853
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H17N3O2
References
– [1]Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.
CAS Number
– 1215313-19-1
Molecular Weight
– 307.35
SMILES
– O=C1CCC(C2=CC=C(/N=C/C3=CC=C(OC)C=C3)C=C2)=NN1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Raf
Isoform
– BRaf
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
