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Products Details
Product Description
– B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].
Web ID
– HY-147852
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C15H16N6O3
References
– [1]Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.
CAS Number
– 2477725-07-6
Molecular Weight
– 328.33
SMILES
– O=C(C1=C(N)N(C2=CC=C(C(CC3)=NNC3=O)C=C2)N=N1)OCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Raf
Isoform
– BRaf
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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