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Products Details
Product Description
– Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC50 of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity[1].
Web ID
– HY-147760
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C27H32N6O4
References
– [1]Allegretti PA, et al. Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem. 2020 Jan 1;28(1):115193.
Molecular Weight
– 504.58
SMILES
– CCOC(C1=C(C2=NC(C3=CC(N)=NC=C3)=CC=C2N=C1)N[C@H]4CC[C@@H](CC4)C(N5CCOCC5)=O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– DYRK
Isoform
– DYRK1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
