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Products Details
Product Description
– PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with Ki values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC50 of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively[1].
Web ID
– HY-147757
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C18H18ClIN6O3Se
References
– [1]An S, et al. Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. Bioorg Med Chem. 2020 Jan 1;28(1):115226.
CAS Number
– 2089159-00-0
Molecular Weight
– 607.69
SMILES
– O[C@H]1[C@H]([C@@H]([Se][C@@H]1C(NC)=O)N2C3=C(N=C2)C(NCC4=CC=CC(I)=C4)=NC(Cl)=N3)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– PPAR
Isoform
– PPARγ;PPARδ
Pathway
– Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
