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Products Details
Product Description
– AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].
Web ID
– HY-147513
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C42H46N2O7S
References
– [1]Yang J, et al. Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway. Eur J Med Chem. 2020;186:111898.
CAS Number
– 2396718-52-6
Molecular Weight
– 722.89
SMILES
– [H][C@@]12CC3=CC=C(OC4=CC(C[C@]5(C6=C(C(OC(C7CCCS7)=O)=C(C=C6CCN5C)OC)OC8=C(C=C(C2=C8)CCN1C)OC)[H])=CC=C4OC)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;Apoptosis
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
