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Resminostat (hydrochloride)
$224 – $1,122
Products Details
Product Description
– Resminostat hydrochloride is a potent inhibitor of HDAC1, HDAC3 and HDAC6, with mean IC50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC50 of 877 nM.
Web ID
– HY-14718A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H20ClN3O4S
Citations
– Methods Mol Biol. 2018;1711:351-398.|Acta Pharmacol Sin. 2021 Apr 13.
References
– [1]Mandl-Weber S, et al. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol. 2010 May;149(4):518-28.|[2]Enzenhofer E, et al. Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines. Head Neck. 2017 May;39(5):900-907.|[3]Peng X, et al. mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat. Biochem Biophys Res Commun. 2016 Sep 2;477(4):556-562.
CAS Number
– 1187075-34-8
Molecular Weight
– 385.87
Compound Purity
– 99.12
SMILES
– O=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1.Cl
Clinical Information
– Phase 4
Research Area
– Cancer
Solubility
– DMSO : ≥ 50 mg/mL|H2O : 7.14 mg/mL (ultrasonic)
Target
– HDAC
Isoform
– HDAC1;HDAC3;HDAC6;HDAC8
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
